What is a quadruple marker test in pregnancy?

A quadruple marker test in pregnancy is a blood test designed to check for the risk of birth defects. You should get a quadruple marker test done when you are at a higher risk of having a child with birth defects. It is also an important screening examination that all pregnant women should perform.

When is a quadruple marker test performed?

The quadruple marker test is performed during the second trimester of pregnancy, typically ranging from between 15 weeks and 20 weeks of pregnancy. It is an important test to check for the risk of Down’s syndrome, Edward’s syndrome, Spina bifida, abdominal wall defects, and other important conditions.

A normal test result indicates that you are having a baby with no risk of a birth defect as detected in the test.



What markers are tested within a quadruple marker test?

The quadruple marker screen test checks your risk of having a baby with a birth defect. The quadruple marker test is designed to check for 4 key parameters. It tests for alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG). The screening examination also checks for uE3 and inhibin-A which are hormones produced by the placenta.


A quadruple marker test in pregnancy is important to screen for risks


In what cases is the test recommended to pregnant women?

There are several conditions under which the test is highly recommended to pregnant women. These are as follows.

Pregnant over the age of 35

In the event that the woman is over the age of 35 years, the risk factor rises which is why the test is recommended.

Managing a chronic condition

If you have a chronic condition such as diabetes, and are pregnant then you should definitely get the quadruple marker screening performed.

Family history

If you have a family history of birth defects or cognitive developmental issues, then getting a screening test performed is important. 

What other marker tests are critical to perform for pregnant women?

It is important to get two other marker tests during the course of your pregnancy.

Double Marker test

In a double marker test, the parameters of human chorionic gonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) are measured.

Triple Marker test

In a triple marker test, your levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated estriol (uE3) are checked.

Anomalies in these marker levels can provide a better insight into the risk factors of the foetus having developmental conditions. 

Are there special requirements for the test?

No you don't need any special preparations for the quadruple marker test.

Where can I buy the quadruple marker test in India?

You can acquire the quad marker test in India through MyDiagnostics.

What is the cost of the quad screen test in India?

You can get the quadruple marker test price via MyDiagnostics. The quadruple marker pregnancy test cost is INR 3000 for the second trimester test.

Can I get tested at home for quadruple marker test?

Yes, you can get an at-home sample collection done with your results emailed directly to you within 24-48 hours in most cases.